Description

(S)-3-(Methylamino)-1-(2-Thienyl)-1-Propanol is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its primary value lies in its role as a key building block for the production of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. This compound is essential for research and manufacturing chemists in the pharmaceutical and fine chemical industries who require enantiomerically pure materials for the development of new therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used as a precursor or reagent in stereoselective chemical reactions to introduce specific chirality.
• Neurological Research: Serves as a key structural component in the development of compounds for central nervous system (CNS) drug discovery programs.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for complex drug molecules in pilot plants and commercial manufacturing.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(S)-3-(Methylamino)-1-(2-Thienyl)-1-Propanol
CAS No.	116539-55-0
Molecular Formula	C8H13NOS
Molecular Weight	171.26 g/mol
Synonyms	(S)-3-(Methylamino)-1-(thiophen-2-yl)propan-1-ol; (S)-1-(2-Thienyl)-3-(methylamino)-1-propanol; (S)-N-Methyl-3-(2-thienyl)-3-hydroxypropylamine; Duloxetine Intermediate; LY248686 Intermediate; (S)-N-Methyl-γ-(2-thienyl)homoveratrylamine alcohol
EINECS	Contact for details

Quality Control

Our (S)-3-(Methylamino)-1-(2-Thienyl)-1-Propanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). The COA includes data for critical parameters such as identity (IR, NMR), assay (HPLC), enantiomeric excess (Chiral HPLC), and related substances. We are committed to meeting the stringent requirements of pharmaceutical development and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged operations to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.