Description

3-(4-Chlorophenyl)-4-Cyano-5-(Methylthio)Thiophene-2-Carboxylic Acid is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate complex thiophene motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a key building block for developing next-generation herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Used in the development of organic semiconductors, conductive polymers, and non-linear optical (NLO) materials due to its electron-rich thiophene core.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-(4-Chlorophenyl)-4-Cyano-5-(Methylthio)Thiophene-2-Carboxylic Acid
CAS No.	116525-66-7
Molecular Formula	C13H8ClNO2S2
Molecular Weight	309.79 g/mol
Synonyms	2-Thiophenecarboxylic acid, 3-(4-chlorophenyl)-4-cyano-5-(methylthio)-; 3-(p-Chlorophenyl)-4-cyano-5-(methylthio)thiophene-2-carboxylic acid; 5-(Methylthio)-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic acid; 4-Cyano-3-(4-chlorophenyl)-5-(methylthio)thiophene-2-carboxylic acid; Thiophene-2-carboxylic acid derivative (116525-66-7); 3-(4-Chlorophenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-(4-Chlorophenyl)-4-Cyano-5-(Methylthio)Thiophene-2-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.