Description

5-Bromo-3-(1-Methyl-1,2,3,6-Tetrahydro-Pyridin-4-Yl)-1H-Indole CAS NO 116480-53-6 is a high-purity, advanced pharmaceutical intermediate characterized by its unique indole and tetrahydro-pyridine fused heterocyclic structure. This compound is of significant commercial importance as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially in neurological and psychiatric research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the design of new chemical entities.
• API Synthesis: Used in the production route for complex molecules where the bromo-indole moiety is essential for biological activity.
• Biochemical Research: Employed as a standard or reference compound in analytical method development and validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Detail
Product Name	5-Bromo-3-(1-Methyl-1,2,3,6-Tetrahydro-Pyridin-4-Yl)-1H-Indole
CAS No.	116480-53-6
Molecular Formula	C14H15BrN2
Molecular Weight	291.19 g/mol
Synonyms	5-Bromo-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole; 5-Bromo-3-(1-methyl-4-piperidinyl)-1H-indole; 1H-Indole, 5-bromo-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-; 116480-53-6; 5-Bromo-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-indole; 5-Bromo-3-(1-methyl-4-piperidenyl)indole; 5-Bromo-3-(1-methyl-δ³-piperidyl)indole
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-(1-Methyl-1,2,3,6-Tetrahydro-Pyridin-4-Yl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.