Description

S-(n-Monomethoxytritylaminoethyl)-o-(2-Chlorophenyl)Phosphorothioate is a sophisticated phosphorothioate derivative, a key intermediate in the synthesis of oligonucleotides and other advanced biomolecules. This compound matters for its critical role in the production of antisense oligonucleotides and therapeutic nucleic acids, where precise chemical modification is essential for stability and efficacy. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and fine chemical manufacturers engaged in the development of next-generation genetic medicines and molecular diagnostics.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense Therapy Development: Used in the research and production of antisense oligonucleotides designed to target specific RNA sequences.
• siRNA and miRNA Synthesis: Serves as a building block for creating small interfering RNA (siRNA) and microRNA (miRNA) analogs with enhanced nuclease resistance.
• Pharmaceutical Intermediates: A high-value intermediate in the multi-step synthesis of novel therapeutic agents.
• Molecular Probe Development: Utilized in creating labeled nucleic acid probes for diagnostic assays and genomic research.
• Bioconjugation Chemistry: The reactive groups enable its use in linking nucleic acids to other molecules, such as peptides or fluorophores.

Basic Information

Product Name	S-(n-Monomethoxytritylaminoethyl)-o-(2-Chlorophenyl)Phosphorothioate
CAS No.	116454-97-8
Molecular Formula	C39H39ClNO4PS
Molecular Weight	684.21 g/mol
Synonyms	MMT-CEP Phosphoramidite; 2-Chlorophenyl S-[2-[(4-Methoxyphenyl)diphenylmethyl]amino]ethyl] O-(2-Chlorophenyl) Phosphorothioate; 5'-O-DMT-2'-O-(2-Methoxyethyl)-N6-Benzoyl-Adenosine-3'-[(2-Cyanoethyl)-(N,N-Diisopropyl)]-Phosphoramidite (related class); Aminoethyl Phosphorothioate MMT Ester; Oligonucleotide Synthesis Reagent; Nucleic Acid Intermediate
EINECS	Contact for details

Quality Control

Our S-(n-Monomethoxytritylaminoethyl)-o-(2-Chlorophenyl)Phosphorothioate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (typically ≥95%), to ensure consistency and compliance with research-grade standards. Certificates of Analysis (COA) detailing specific batch results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., argon or nitrogen) after opening to prevent degradation. For long-term stability, storage at -20°C is recommended.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.