Description

Tulopafant CAS NO 116289-53-3 is a potent and selective platelet-activating factor (PAF) receptor antagonist. This compound is of significant interest in pharmacological research for its ability to modulate inflammatory and allergic responses mediated by PAF. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for researchers and developers in the pharmaceutical and biotechnology sectors.

Application

• Pharmacological Research: Used as a reference standard in studies investigating the role of Platelet-Activating Factor (PAF) in inflammation, allergy, and anaphylaxis.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the synthesis of novel PAF receptor antagonists for therapeutic applications.
• Biochemical Assays: Employed in in vitro and in vivo assays to characterize PAF receptor binding and signal transduction pathways.
• Academic Research: Utilized in university and institutional labs for fundamental studies on cardiovascular and immune system pharmacology.
• Pharmaceutical Manufacturing: Acts as a high-purity starting material or intermediate in the GMP-compliant production of specialized APIs.
• Toxicology Studies: Applied in research to understand the protective effects of PAF antagonism in various disease models, including ischemia and shock.

Basic Information

Product Name	Tulopafant
CAS No.	116289-53-3
Molecular Formula	C27H29N3O4
Molecular Weight	459.54 g/mol
Synonyms	WEB 2086; WEB-2086; Tulopafant (WEB 2086); 3-(4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl)-1-(4-morpholinyl)-1-propanone; 1-(4-Morpholinyl)-3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepin-2-yl]-1-propanone; Boehringer Ingelheim WEB 2086
EINECS	Contact for details

Quality Control

Our Tulopafant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets high-grade standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.