Description

1-[(tert-Butyldimethylsilanyl)Oxy]Propan-2-Ol is a versatile organosilicon-protected alcohol derivative, specifically a tert-butyldimethylsilyl (TBDMS) ether of isopropanol. This compound is a critical intermediate and protecting group reagent in advanced organic synthesis, offering exceptional stability under a wide range of reaction conditions. It is primarily utilized by pharmaceutical, agrochemical, and fine chemical R&D and manufacturing teams for the selective protection of hydroxyl groups, enabling complex multi-step syntheses with high yields and purity.

Application

• Pharmaceutical Intermediate: A key building block and protecting group reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for complex molecules like steroids, nucleosides, and antibiotics.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators where selective hydroxyl protection is required.
• Fine Chemical Manufacturing: Serves as a crucial intermediate in the synthesis of specialty chemicals, flavors, fragrances, and advanced materials.
• Academic & Industrial Research: Employed in laboratory-scale organic synthesis and process development for novel compound libraries and route scouting.
• Peptide & Carbohydrate Chemistry: Facilitates the selective protection of hydroxyl groups in the synthesis of complex peptides, oligosaccharides, and glycoconjugates.
• Material Science Precursor: Acts as a functional monomer or modifying agent in the development of specialized silicone-based polymers and surface coatings.

Basic Information

Product Name	1-[(tert-Butyldimethylsilanyl)Oxy]Propan-2-Ol
CAS No.	116286-81-8
Molecular Formula	C9H22O2Si
Molecular Weight	190.36 g/mol
Synonyms	1-[(tert-Butyldimethylsilyl)oxy]-2-propanol; 2-Propanol, 1-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 1-(tert-Butyldimethylsiloxy)-2-propanol; 1-(TBDMSO)-2-propanol; 1-Hydroxy-2-(tert-butyldimethylsiloxy)propane; 1-(tert-Butyldimethylsilyloxy)propan-2-ol; Isopropyl TBDMS ether (derivative); TBDMS ether of 1,2-propanediol (monoether)
EINECS	Contact for details

Quality Control

Our 1-[(tert-Butyldimethylsilanyl)Oxy]Propan-2-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture uptake. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.