Description

5-Chloro-2-Fluoroiodobenzene is a high-purity halogenated benzene derivative, serving as a critical building block in advanced organic synthesis. Its unique combination of chlorine, fluorine, and iodine substituents makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores for bioactivity or as synthetic handles for further functionalization.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides, where the halogen atoms can influence binding affinity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to the reactive iodine atom, enabling efficient carbon-carbon bond formation.
• Fluorine Chemistry: The fluorine atom provides metabolic stability and influences lipophilicity, making it valuable in medicinal chemistry for lead optimization.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for screening.

Basic Information

Item	Details
Product Name	5-Chloro-2-Fluoroiodobenzene
CAS No.	116272-42-5
Molecular Formula	C6H3ClFI
Molecular Weight	256.44 g/mol
Synonyms	1-Chloro-4-fluoro-2-iodobenzene; 2-Fluoro-5-chloroiodobenzene; 4-Fluoro-2-iodo-1-chlorobenzene; 5-Chloro-2-fluoro-1-iodobenzene; (5-Chloro-2-fluorophenyl)iodide; Benzene, 1-chloro-4-fluoro-2-iodo-; 116272-42-5 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-Fluoroiodobenzene is manufactured under strict quality management systems. We guarantee high chemical purity and consistency, supported by comprehensive analytical testing including GC, HPLC, and NMR. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Purity (HPLC/GC)	≥99.0% (High Purity Grade)
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.