Description

4-Bromo-1-Fluoro-2-Iodobenzene is a high-purity halogenated benzene derivative, a crucial building block in advanced organic synthesis. Its unique combination of bromo, fluoro, and iodo substituents on the aromatic ring makes it a versatile and highly functionalized intermediate for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it is used to introduce halogen atoms for further cross-coupling reactions or to modulate the electronic properties of target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores for bioactivity or as handles for further functionalization via Suzuki, Stille, or Sonogashira cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the halogen atoms can be critical for efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for creating halogenated aromatic components in advanced electronic materials, influencing charge transport and luminescent properties.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis, where the halogen atoms can be modified to fine-tune steric and electronic properties.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in synthetic organic chemistry for exploring new reaction pathways and constructing complex, polyfunctionalized arenes.
• Polymer Modification: Can be used to introduce halogenated aromatic units into polymer backbones or side chains, altering physical properties like thermal stability or refractive index.

Basic Information

Product Name	4-Bromo-1-Fluoro-2-Iodobenzene
CAS No.	116272-41-4
Molecular Formula	C6H3BrFI
Molecular Weight	300.90 g/mol
Synonyms	1-Bromo-4-fluoro-2-iodobenzene; 2-Iodo-4-bromofluorobenzene; 4-Bromo-2-iodofluorobenzene; 4-Bromo-2-iodo-1-fluorobenzene; (4-Bromo-2-iodophenyl) fluoride; Benzene, 1-bromo-4-fluoro-2-iodo-; 116272-41-4
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Fluoro-2-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment ensures material consistency and reliability for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.