Description

2-Azabicyclo[2.1.1]hexane-1-carboxylic acid hydrochloride is a high-purity, bicyclic amino acid derivative hydrochloride salt, serving as a critical building block in advanced organic synthesis. Its constrained, rigid bicyclic structure makes it a valuable scaffold for medicinal chemistry, enabling the exploration of novel three-dimensional chemical space in drug discovery. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in protease inhibitor and central nervous system (CNS) therapeutic programs.
• Medicinal Chemistry Research: Used as a constrained scaffold to modulate the pharmacokinetic properties, potency, and selectivity of lead compounds.
• Peptidomimetics Development: Employed to create conformationally restricted peptide analogs with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor for novel active ingredients with unique modes of action in crop protection.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Asymmetric Catalysis Ligand Precursor: Potential starting material for the synthesis of novel chiral ligands and organocatalysts.

Basic Information

Item	Details
Product Name	2-Azabicyclo[2.1.1]hexane-1-carboxylic acid hydrochloride
CAS No.	116129-07-8
Molecular Formula	C7H11NO2 · HCl
Molecular Weight	177.63 g/mol
Synonyms	1-Azabicyclo[2.1.1]hexane-2-carboxylic acid hydrochloride; (1R,2S,4S)-2-Azabicyclo[2.1.1]hexane-1-carboxylic acid hydrochloride; 2-Azabicyclo[2.1.1]hexane-1-carboxylic acid HCl; 2-Azabicyclo[2.1.1]hexane-1-carboxylic acid hydrochloride salt; Bicyclic proline derivative hydrochloride; 1-Carboxy-2-azabicyclo[2.1.1]hexane hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Azabicyclo[2.1.1]hexane-1-carboxylic acid hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.