Description

5-(4-Hydroxyphenyl)Thiophene-2-Carboxylic Acid is a high-purity organic building block featuring a hydroxyphenyl-substituted thiophene carboxylic acid structure, offering versatile reactivity for advanced synthesis. This compound is valued for its role as a critical intermediate in the development of complex molecules, particularly in pharmaceutical and advanced material research. It is essential for chemists and manufacturers in the life sciences, agrochemical, and specialty chemical industries seeking to incorporate functionalized heterocyclic motifs into their target compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for molecules containing thiophene and phenolic moieties.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and plant growth regulators that leverage its unique heterocyclic core.
• Material Science Research: Serves as a monomer or functional precursor in the development of conductive polymers, organic semiconductors, and advanced organic frameworks (MOFs/COFs).
• Ligand and Catalyst Development: The carboxylic acid and phenolic groups make it a versatile starting point for designing chelating ligands and organocatalysts.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments where the thiophene ring contributes to color and stability properties.
• Bioconjugation and Probe Chemistry: Acts as a functional handle for attaching fluorophores, tags, or other molecules in diagnostic and biochemical research.

Basic Information

Product Name	5-(4-Hydroxyphenyl)Thiophene-2-Carboxylic Acid
CAS No.	116016-57-0
Molecular Formula	C11H8O3S
Molecular Weight	220.24 g/mol
Synonyms	5-(4-Hydroxyphenyl)-2-thiophenecarboxylic acid; 2-Thiophenecarboxylic acid, 5-(4-hydroxyphenyl)-; 4-(5-Carboxy-2-thienyl)phenol; 5-(p-Hydroxyphenyl)thiophene-2-carboxylic acid; 5-(4-Hydroxy-phenyl)-thiophene-2-carboxylic acid; 5-(4-Hydroxyphenyl)thiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of 5-(4-Hydroxyphenyl)Thiophene-2-Carboxylic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, NMR, and MS for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.