Description

1-Acetyl-6-Iodoindoline is a versatile halogenated indoline derivative, a key synthetic intermediate prized for its reactivity in cross-coupling reactions. Its core value lies in enabling the efficient construction of complex heterocyclic scaffolds, which are fundamental to modern pharmaceutical and agrochemical discovery. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the creation of new herbicides, fungicides, and insecticides, leveraging the iodine atom for further functionalization.
• Material Science: Serves as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where the indoline core contributes to charge transport properties.
• Chemical Synthesis: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex aryl and alkynyl groups.
• Ligand & Catalyst Development: Utilized in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Academic & Contract Research: A valuable reagent for methodological studies and custom synthesis projects in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	1-Acetyl-6-Iodoindoline
CAS No.	115666-43-8
Molecular Formula	C10H10INO
Molecular Weight	287.10 g/mol
Synonyms	6-Iodo-1-acetylindoline; 1-Acetyl-6-iodo-2,3-dihydroindole; N-Acetyl-6-iodoindoline; 6-Iodoindoline-1-acetamide (deprecated); 2,3-Dihydro-1H-indol-1-yl, 6-iodo-, acetate
EINECS	Contact for details

Quality Control

Our 1-Acetyl-6-Iodoindoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.