Description

1,8-Bis-Maleimidotriethyleneglycol is a high-purity, heterobifunctional crosslinking agent featuring maleimide and hydroxyl termini separated by a hydrophilic triethylene glycol spacer. This compound is engineered to enable precise and stable bioconjugation under mild, aqueous conditions, making it a critical tool for advanced research and development. It is primarily utilized by scientists and manufacturers in the biotechnology, pharmaceutical, and diagnostics sectors for creating stable protein-protein conjugates, antibody-drug conjugates (ADCs), and functionalized surfaces or nanoparticles.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a cleavable or non-cleavable linker for attaching cytotoxic payloads to monoclonal antibodies, leveraging the maleimide group's specificity for thiols.
• Protein/Peptide Crosslinking: Enables site-specific conjugation between proteins, peptides, or other biomolecules containing free thiol and hydroxyl groups for structural studies or multimer creation.
• Surface Functionalization: Used to modify gold nanoparticles, biosensor chips, or chromatographic resins with biomolecules via the maleimide-thiol "click" chemistry.
• Polymer Modification: Acts as a crosslinker or functional end-group in the synthesis of hydrogels, smart polymers, and drug delivery systems requiring biocompatibility.
• Diagnostic Reagent Synthesis: Employed in the development of enzyme-linked immunosorbent assays (ELISA), lateral flow assays, and other diagnostic tools by conjugating enzymes or labels to antibodies.
• Biomaterial Engineering: Facilitates the creation of bioactive scaffolds for tissue engineering by covalently immobilizing growth factors or cell-adhesion peptides.

Basic Information

Product Name	1,8-Bis-Maleimidotriethyleneglycol
CAS No.	115597-84-7
Molecular Formula	C18H24N2O8
Molecular Weight	396.40 g/mol
Synonyms	BM(PEG)3; 1,8-Bis(maleimido)triethyleneglycol; 1,11-Bis-maleimidotriethyleneglycol; PEG3 bis-maleimide; TEG-bis-maleimide; 3,6,9,12-Tetraoxatetradeca-1,13-diene-1,14-dicarboximide; BM(PEG)3 Crosslinker; 1,1'-(Oxybis(ethane-2,1-diyl))bis(1H-pyrrole-2,5-dione)
EINECS	Contact for details

Quality Control

Our 1,8-Bis-Maleimidotriethyleneglycol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for bioconjugation and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.