Description

Tiagabine is a selective GABA reuptake inhibitor (SGRI) with the CAS registry number 115103-54-3. This compound is a critical active pharmaceutical ingredient (API) valued for its specific neurological activity. It is primarily required by pharmaceutical manufacturers and research institutions developing and producing antiepileptic medications. Our supply ensures high purity and consistent quality for reliable formulation and research outcomes.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of antiepileptic drugs.
• Neurological Research: Used in preclinical and clinical studies to investigate mechanisms of GABAergic neurotransmission.
• Reference Standard: Serves as a high-purity analytical standard for quality control laboratories in pharmaceutical production.
• Formulation Development: Employed in R&D for developing new dosage forms, such as tablets or capsules, containing Tiagabine.
• Biochemical Studies: Utilized in vitro studies to understand its binding affinity and selectivity for the GABA transporter GAT-1.

Basic Information

Product Name	Tiagabine
CAS No.	115103-54-3
Molecular Formula	C20H25NO2S2
Molecular Weight	375.55 g/mol
Synonyms	Tiagabine Hydrochloride; (R)-(-)-Tiagabine; (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-en-1-yl]nipecotic Acid; Gabitril; NNC-05-0328; NO-05-0328; TGB; GAT-1 Inhibitor
EINECS	Contact for details

Quality Control

Our Tiagabine is manufactured under strict quality systems to meet the rigorous standards required for pharmaceutical intermediates and APIs. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, ensuring traceability and consistency for our global B2B clients in the pharmaceutical sector.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.