Description

1,3-Dioxolo[4,5-G]Isoquinoline-5-Methanol, 6-(2,2-Dimethyl-1-Oxopropyl )-5,6,7,8-Tetrahydro-α-[2-(Hydroxymethyl)-3,4-Dimethoxyphenyl]-, ( R*,S*)-(+/-)- is a complex, multi-functional heterocyclic compound that serves as a critical synthetic intermediate or building block in advanced organic synthesis. Its intricate molecular architecture, featuring fused dioxole and isoquinoline rings with multiple chiral centers and functional groups, makes it a valuable precursor for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing sophisticated molecular targets.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex alkaloids, potential drug candidates, and other bioactive molecules targeting the central nervous system or other therapeutic areas.
• Agrochemical Research: Used in the development of novel pesticides or herbicides, leveraging its heterocyclic core for biological activity.
• Organic Synthesis & Catalysis: Serves as a chiral ligand precursor or a sophisticated substrate in asymmetric synthesis and catalysis research.
• Fine Chemical Production: Intermediate for manufacturing specialty dyes, pigments, or advanced materials requiring specific optical or electronic properties.
• Academic & Contract Research: Essential material for methodological studies in total synthesis, medicinal chemistry, and chemical biology within university and CRO laboratories.

Basic Information

Product Name	1,3-Dioxolo[4,5-G]Isoquinoline-5-Methanol, 6-(2,2-Dimethyl-1-Oxopropyl )-5,6,7,8-Tetrahydro-α-[2-(Hydroxymethyl)-3,4-Dimethoxyphenyl]-, ( R*,S*)-(+/-)-
CAS No.	114621-94-2
Molecular Formula	C26H31NO7
Molecular Weight	469.53 g/mol
Synonyms	(±)-6-(2,2-Dimethylpropanoyl)-5,6,7,8-tetrahydro-α-[2-(hydroxymethyl)-3,4-dimethoxyphenyl]-1,3-dioxolo[4,5-g]isoquinoline-5-methanol; 1,3-Dioxolo[4,5-g]isoquinoline-5-methanol, 6-(2,2-dimethyl-1-oxopropyl)-5,6,7,8-tetrahydro-α-[2-(hydroxymethyl)-3,4-dimethoxyphenyl]-, (±)-; Tetrahydroisoquinoline derivative 114621-94-2; THIQ-based chiral intermediate; Dioxolo-isoquinoline methanol derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development and scale-up projects with custom purity grades and specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0% (Area Percent)
Purity (HPLC)	≥ 98.0% (Total related substances ≤ 2.0%)
Water Content (KF)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.