Description

Mmt-Hexylamine-Linker Amidite 0.15G, Ab is a specialized phosphoramidite monomer used in the solid-phase synthesis of oligonucleotides. This compound is critical for introducing a hexylamine linker group, enabling the subsequent conjugation of reporter molecules, peptides, or other functional groups to synthetic DNA or RNA strands. It is an essential reagent for researchers and manufacturers in the fields of molecular diagnostics, therapeutic oligonucleotide development, and advanced bioconjugation.

Application

• Oligonucleotide Synthesis: Key building block for the automated solid-phase synthesis of DNA/RNA strands containing a primary amine linker.
• Probe and Primer Labeling: Enables the site-specific attachment of fluorescent dyes, quenchers, biotin, or other tags for FISH probes, qPCR assays, and microarray applications.
• Therapeutic Oligonucleotide Manufacturing: Used in the production of antisense oligonucleotides, siRNA, and aptamers that require functionalization for targeting or pharmacokinetic optimization.
• Bioconjugation Platform: Provides a stable amine handle for coupling to proteins, peptides, nanoparticles, or solid surfaces, creating hybrid biomolecules.
• Diagnostic Kit Development: Integral for creating sensitive and specific detection probes used in clinical and research diagnostic kits.
• Materials Science: Facilitates the creation of DNA-functionalized surfaces and materials for biosensors and nano-assembly.

Basic Information

Product Name	Mmt-Hexylamine-Linker Amidite 0.15G, Ab
CAS No.	114616-27-2
Molecular Formula	C₃₈H₄₈N₃O₇P
Molecular Weight	689.78 g/mol
Synonyms	5'-Dimethoxytrityl-1',2'-Dideoxy-1'-[N-(6-trifluoroacetylaminohexyl)-3-aminopropyl]ribofuranoside-3'-[2-Cyanoethyl-N,N-diisopropylphosphoramidite]; 6-(Trifluoroacetamido)hexyl-1-[(2-cyanoethoxy)(diisopropylamino)phosphino]-3-O-(4,4'-dimethoxytrityl)-2-deoxypropyl-1,3-diol; Mmt-Hexylamine Phosphoramidite; Amine Modifier C6 Phosphoramidite; 5'-MMT-6-aminohexyl-1,3-propanediol, 3-[2-cyanoethyl(diisopropylamino)phosphoramidite]; Hexylamino Linker Amidite; Amino Modifier C6; 5'-O-Dimethoxytrityl-N-(6-trifluoroacetylaminobexyl)-3-amino-1,2-propanediol,3-[O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite]
EINECS	Contact for details

Quality Control

Every batch of Mmt-Hexylamine-Linker Amidite is manufactured and tested under strict quality management systems. We ensure high purity and consistency through rigorous analytical controls, including HPLC, 31P NMR, and 1H NMR analysis. Certificates of Analysis (COA) with detailed chromatographic data and spectroscopic confirmation are provided with each shipment to guarantee the product meets the exacting standards required for oligonucleotide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store the product in a freezer at -20°C or below under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and easily oxidized nature. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Retention time corresponds to reference standard
Identification (31P NMR)	Spectrum corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.