Description

tert-Butyl 2-Formyl-1H-Indole-1-Carboxylate is a high-value, protected indole derivative that serves as a versatile and critical building block in advanced organic synthesis. Its core value lies in providing a reactive formyl group at the 2-position of the indole ring while the nitrogen is protected by a tert-butoxycarbonyl (Boc) group, enabling selective and complex molecular transformations. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active pharmaceutical ingredients (APIs) and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides that leverage the indole scaffold for biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of advanced organic electronic materials and dyes.
• Academic & R&D Laboratories: Employed as a standard reagent for methodological development in organic chemistry, particularly in palladium-catalyzed cross-couplings and multi-step heterocyclic synthesis.
• Peptidomimetics & Bioconjugation: The reactive aldehyde group allows for conjugation and the construction of peptidomimetic structures for biochemical applications.

Basic Information

Product Name	tert-Butyl 2-Formyl-1H-Indole-1-Carboxylate
CAS No.	114604-96-5
Molecular Formula	C14H15NO3
Molecular Weight	245.27 g/mol
Synonyms	1-Boc-2-formylindole; 1-(tert-Butoxycarbonyl)-2-formylindole; 2-Formyl-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 2-formylindole-1-carboxylate; 1-Boc-indole-2-carboxaldehyde; BOC-2-CHO-Indole; 2-Carbaldehyde-1-(tert-butoxycarbonyl)indole; 114604-96-5
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Formyl-1H-Indole-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.