Description

α-Tocopherol-[D6] (Vitamin E-[D6]) is a deuterium-labeled isotopologue of the essential fat-soluble antioxidant, α-tocopherol. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in quantitative analytical methods, particularly mass spectrometry. It serves as an indispensable internal standard for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and food science industries who require precise measurement of Vitamin E levels in complex matrices.

Application

• Internal Standard for Quantitative Analysis: Primary use as a reference standard in LC-MS/MS, GC-MS, and HPLC methods for the accurate quantification of α-tocopherol in biological samples, pharmaceuticals, and food products.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables tracing and quantification of Vitamin E and its metabolites in in-vivo and in-vitro studies to understand absorption, distribution, metabolism, and excretion.
• Clinical Research and Diagnostics: Used in assays to measure Vitamin E status in serum or plasma, supporting research on nutritional deficiencies, oxidative stress, and related health conditions.
• Pharmaceutical Quality Control (QC): Ensures assay accuracy and method validation for Vitamin E content in finished drug products, raw materials, and dietary supplements.
• Nutraceutical and Food Fortification Analysis: Critical for verifying label claims and ensuring consistent potency of Vitamin E in fortified foods, infant formula, and nutritional supplements.
• Stable Isotope Labeling in Biochemistry: Facilitates mechanistic studies of antioxidant activity, membrane dynamics, and the role of Vitamin E in cellular processes without isotopic interference.

Basic Information

Product Name	α-Tocopherol-[D6] (Vitamin E-[D6])
CAS No.	113892-08-3
Molecular Formula	C29H44D6O2
Molecular Weight	436.72 g/mol
Synonyms	(+)-α-Tocopherol-d6; (2R,4'R,8'R)-α-Tocopherol-d6; 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol-d6; 5,7,8-Trimethyltocol-d6; d6-α-Tocopherol; Vitamin E-d6 (alpha form); Deuterated Vitamin E; 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol-d6
EINECS	Contact for details

Quality Control

Our α-Tocopherol-[D6] is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and confirmation of structure by NMR and MS. We adhere to relevant standards for high-purity reference materials to guarantee reliable and reproducible performance as an internal standard.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow viscous oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.