Description

5-Thiazoleacetonitrile, α-Hydroxy-2-Methyl- is a specialized heterocyclic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a thiazole core with a functionalized acetonitrile side chain, making it a versatile precursor for constructing complex pharmacophores and agrochemical intermediates. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel thiazole-containing drug candidates, particularly in antiviral and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the bioactivity of the thiazole moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its electron-withdrawing nitrile group.
• Chemical Biology Probes: Utilized to develop molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring high-purity, complex heterocycles.

Basic Information

Product Name	5-Thiazoleacetonitrile, α-Hydroxy-2-Methyl-
CAS No.	113732-80-2
Molecular Formula	C6H6N2OS
Molecular Weight	154.19 g/mol
Synonyms	2-Methyl-α-hydroxy-5-thiazoleacetonitrile; (2-Methyl-1,3-thiazol-5-yl)(hydroxy)acetonitrile; 5-Thiazoleacetonitrile, α-hydroxy-2-methyl-; 2-Methyl-5-thiazoleglycolonitrile; α-Hydroxy-2-methyl-5-thiazoleacetonitrile; (Hydroxy)(2-methyl-1,3-thiazol-5-yl)acetonitrile
EINECS	Contact for details

Quality Control

Our 5-Thiazoleacetonitrile, α-Hydroxy-2-Methyl- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.