Description

(4-Fluorophenyl)Acetic-2,2-D2 Acid is a deuterated derivative of 4-fluorophenylacetic acid, a valuable building block in synthetic organic chemistry. This compound is specifically designed for applications requiring isotopic labeling, offering enhanced metabolic stability and traceability in research. It is primarily utilized by pharmaceutical R&D teams and advanced material scientists for the synthesis of deuterated drug candidates and as a probe in mechanistic studies. The product is supplied to meet the stringent purity requirements of high-value chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of deuterated active pharmaceutical ingredients (APIs) in drug discovery and development.
• Metabolic Studies: Used as a stable isotope-labeled internal standard in LC-MS and GC-MS for quantitative bioanalysis and pharmacokinetic research.
• Mechanistic Probe: Employed in reaction mechanism elucidation and kinetic isotope effect (KIE) studies due to the carbon-deuterium bond.
• Material Science Research: Serves as a specialty monomer or precursor for advanced polymers and organic electronic materials requiring fluorinated, deuterated components.
• Agrochemical Development: Intermediate in the research and synthesis of novel, isotopically labeled agrochemicals.
• Academic & Contract Research: Essential reagent for universities and CROs conducting cutting-edge synthetic and analytical chemistry projects.

Basic Information

Product Name	(4-Fluorophenyl)Acetic-2,2-D2 Acid
CAS No.	113715-48-3
Molecular Formula	C8H5D2FO2
Molecular Weight	157.15 g/mol
Synonyms	2,2-Dideutero-2-(4-fluorophenyl)acetic acid; (4-Fluorophenyl)acetic-2,2-d2 acid; 4-Fluorobenzeneacetic-2,2-d2 Acid; p-Fluorophenylacetic-2,2-d2 Acid; 2-(4-Fluorophenyl)acetic-2,2-d2 Acid; [2,2-2H2]-4-Fluorophenylacetic Acid; Deutero-4-FPA; 4-FPAA-d2
EINECS	Contact for details

Quality Control

Our (4-Fluorophenyl)Acetic-2,2-D2 Acid is manufactured under controlled conditions to ensure high chemical and isotopic purity. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ²H) for deuterium incorporation and positional purity, HPLC for chemical purity, and MS for identity confirmation. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, including assay, isotopic enrichment, and impurity profiles, to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (²H NMR)	≥ 98 atom % D at C-2
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.