Description

(2-Azidoethoxy)(tert-Butyl)Dimethylsilane is a specialized organosilicon reagent featuring a protected azidoethyl functionality. This compound is critically important as a versatile building block in organic synthesis and materials science, enabling the controlled introduction of azide groups for subsequent "click chemistry" reactions. It is primarily needed by researchers and manufacturers in the pharmaceutical, bioconjugation, and polymer industries for applications such as drug discovery, surface modification, and the development of functional materials.

Application

• Click Chemistry Reagent: Serves as a key precursor for Huisgen 1,3-dipolar cycloaddition reactions with alkynes, enabling efficient bioconjugation and polymer functionalization.
• Pharmaceutical Intermediate: Used in the synthesis of complex drug molecules and prodrugs where a protected, bio-orthogonal azide handle is required for targeted delivery or labeling.
• Polymer & Materials Science: Employed to introduce azide functionalities into polymer backbones or surfaces for creating cross-linked networks, hydrogels, or smart materials.
• Bioconjugation & Probe Synthesis: Facilitates the labeling of biomolecules (proteins, antibodies, oligonucleotides) with fluorescent dyes, affinity tags, or other payloads via stable triazole linkages.
• Surface Modification: Used to functionalize silicon, glass, or metal oxide surfaces with azide groups for subsequent immobilization of ligands or catalysts.
• Glycochemistry & Carbohydrate Synthesis: Acts as a glycosyl donor or spacer arm precursor in the synthesis of complex glycoconjugates and neoglycopolymers.

Basic Information

Item	Details
Product Name	(2-Azidoethoxy)(tert-Butyl)Dimethylsilane
CAS No.	113274-21-8
Molecular Formula	C8H19N3OSi
Molecular Weight	201.34 g/mol
Synonyms	1-Azido-2-[(tert-butyldimethylsilyl)oxy]ethane; 2-[(tert-Butyldimethylsilyl)oxy]ethyl azide; 2-Azidoethyl tert-butyldimethylsilyl ether; 2-Azidoethoxy-tert-butyldimethylsilane; tert-Butyl(2-azidoethoxy)dimethylsilane; N3(CH2)2OSiMe2tBu; Azido-PEG1-TBDMS; TBDMS-protected azidoethanol
EINECS	Contact for details

Quality Control

Our (2-Azidoethoxy)(tert-Butyl)Dimethylsilane is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and FT-IR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.