Description

Thiazole, 4-(Trimethylsilyl)- is a high-value organosilicon derivative of the thiazole heterocycle, characterized by the presence of a trimethylsilyl (TMS) protecting group. This compound is a critical synthetic intermediate and building block in advanced organic synthesis, offering enhanced stability and reactivity for constructing complex molecular architectures. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and materials science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides, herbicides, and fungicides due to the bioactivity of the thiazole core.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Organic Synthesis Building Block: The TMS group facilitates specific coupling reactions (e.g., cross-coupling) and acts as a protecting group for further functionalization of the thiazole ring.
• Chemical Research & Development: Essential for method development and exploratory chemistry in academic and industrial R&D laboratories.

Basic Information

Product Name	Thiazole, 4-(Trimethylsilyl)-
CAS No.	112969-78-5
Molecular Formula	C6H11NSSi
Molecular Weight	157.31 g/mol
Synonyms	4-(Trimethylsilyl)thiazole; 4-TMS-thiazole; Thiazole, 4-(trimethylsilyl)-; 4-Trimethylsilylthiazole; 4-(Trimethylsilyl)-1,3-thiazole; 1,3-Thiazole, 4-(trimethylsilyl)-; 4-(TMS)Thiazole; 4-Thiazolyltrimethylsilane
EINECS	Contact for details

Quality Control

Every batch of Thiazole, 4-(Trimethylsilyl)- is manufactured and tested under strict quality management protocols to ensure consistency and purity for research and production applications. Our standard grade meets high-purity specifications suitable for synthetic chemistry. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. Custom synthesis and purification to meet specific project requirements (e.g., >99% HPLC) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.