Description

Diethyl n-[5-Methylamino-2-Thenoyl]-L-Glutamate is a specialized, high-purity chemical intermediate designed for advanced synthesis. This compound matters for its role as a critical building block in the development of complex, biologically active molecules, offering precise stereochemistry and functional group compatibility. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the areas of peptide mimetics and targeted drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to construct non-peptide scaffolds that mimic the structure and function of natural peptides for drug development.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization.
• Bioconjugation: Potential use in creating targeted drug delivery systems through conjugation to antibodies or other biomolecules.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	Diethyl n-[5-Methylamino-2-Thenoyl]-L-Glutamate
CAS No.	112889-02-8
Molecular Formula	C17H24N2O5S
Molecular Weight	368.45 g/mol
Synonyms	L-Glutamic acid, N-[5-(methylamino)-2-thienylcarbonyl]-, diethyl ester; Diethyl N-[(5-methylamino-2-thenoyl)]-L-glutamate; Diethyl (2S)-2-[[5-(methylamino)thiophene-2-carbonyl]amino]pentanedioate; 5-Methylamino-2-thenoyl-L-glutamic acid diethyl ester; (S)-Diethyl 2-((5-(methylamino)thiophene-2-carboxamido)pentanedioate); Glutamate derivative 112889-02-8
EINECS	Contact for details

Quality Control

Our Diethyl n-[5-Methylamino-2-Thenoyl]-L-Glutamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.