Description

Losigamone is a synthetic chemical compound with significant research and development interest in the pharmaceutical sector. Its primary value lies in its potential as a pharmacologically active agent, specifically studied for its anticonvulsant properties. This makes it a critical compound for pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) focused on central nervous system (CNS) therapeutics and novel drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) for neurological research.
• Anticonvulsant Research: Primary application in preclinical and clinical research for the development of new antiepileptic drugs (AEDs).
• Neurological Disorder Studies: Used in academic and industrial research to investigate mechanisms and treatments for various CNS disorders.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Biochemical Research: Utilized in studies exploring ion channel modulation and neuronal excitability.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis and scale-up projects under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	Losigamone
CAS No.	112856-44-7
Molecular Formula	C16H14O4
Molecular Weight	270.28 g/mol
Synonyms	(+)-Losigamone; (3R,4S)-3-Ethyl-4-methyl-1-pyrrolidineacetic acid α-oxo-2-thienylmethyl ester; AO-33; ADD 234040; ADD-234040; ADD234040; Losigamon; Losigamonum
EINECS	Contact for details

Quality Control

Our Losigamone is manufactured and tested to meet stringent quality standards suitable for pharmaceutical research and development. We provide material that typically conforms to high-purity specifications, supported by comprehensive analytical data. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch. Our quality system supports development under research-grade, GMP-grade, or other customized quality protocols as required by your project.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.