Description

(+)-β-Chlorodiisopinocamphenylborane is a highly valuable chiral organoboron reagent, specifically the (+)-enantiomer of β-chlorodiisopinocamphenylborane. This compound matters significantly for its role as a stereoselective reducing agent, enabling the synthesis of enantiomerically pure alcohols and other chiral building blocks. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for asymmetric synthesis.

Application

• Asymmetric Reduction of Prochiral Ketones: Enantioselective synthesis of secondary alcohols, a key step in active pharmaceutical ingredient (API) development.
• Chiral Auxiliary in Organic Synthesis: Used to introduce chirality in complex molecule construction for drug candidates and specialty chemicals.
• Preparation of Enantiomerically Enriched Boronic Esters: Serving as a precursor for Suzuki-Miyaura cross-coupling reactions to form chiral biaryl structures.
• Process Chemistry and Scale-up: Enabling the commercial-scale production of optically pure intermediates under controlled conditions.
• Academic and Industrial R&D: Fundamental research in new methodologies for stereocontrolled carbon-boron and carbon-carbon bond formation.

Basic Information

Product Name	(+)-β-Chlorodiisopinocamphenylborane
CAS No.	112446-73-8
Molecular Formula	C20H34BCl
Molecular Weight	320.75 g/mol
Synonyms	(+)-B-Chlorodiisopinocampheylborane; (+)-Chlorodiisopinocamphenylborane; (1R,2S,5R)-2-Chloro-3,7,7-trimethylbicyclo[3.1.1]hept-2-yl-di-((1R,2S,3R,5R)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl)borane; (+)-B-Chlorodiisopinocampheylborane; Alpine Borane® (related chiral reagent); DIP-Chloride™ (common trade name style); (1R)-(-)-B-Chlorodiisopinocampheylborane (alternate naming); Ipc2BCl
EINECS	Contact for details

Quality Control

Our (+)-β-Chlorodiisopinocamphenylborane is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high enantiomeric excess (ee). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identity. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is between 2°C and 8°C. The container should be kept tightly sealed in a desiccator after each use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 95.0%
Enantiomeric Excess (HPLC or NMR)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.