Description

1-Azabicyclo[3.2.0]Heptane-3,7-Dione,2-(1-Methylethyl)-,(2R-Cis)-(9Ci) is a high-purity, stereochemically defined bicyclic lactam compound. This advanced pharmaceutical intermediate is valued for its rigid molecular scaffold, which is crucial for imparting specific biological activity and metabolic stability in drug molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the areas of enzyme inhibition and targeted small-molecule drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Protease Inhibitor Research: Used in the development of inhibitors targeting specific proteases due to its constrained β-lactam-like structure.
• Medicinal Chemistry: Employed as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Chemical Biology: Acts as a molecular probe or a precursor for activity-based probes to study enzyme function and mechanism.
• Process Chemistry Development: Utilized in route scouting and scale-up optimization for the commercial manufacturing of complex drug candidates.
• Academic Research: Used in universities and research institutes for methodological studies in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-Azabicyclo[3.2.0]Heptane-3,7-Dione,2-(1-Methylethyl)-,(2R-Cis)-(9Ci)
CAS No.	112256-68-5
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	(2R-cis)-2-Isopropyl-1-azabicyclo[3.2.0]heptane-3,7-dione; (2R,5S)-2-Isopropyl-1-azabicyclo[3.2.0]heptane-3,7-dione; 2-Isopropyl-1-azabicyclo[3.2.0]heptane-3,7-dione, (2R-cis)-; cis-2-Isopropyl-1-azabicyclo[3.2.0]heptane-3,7-dione; Bicyclic β-Lactam Intermediate; 2-Isopropyl-1-azabicyclo[3.2.0]heptane-3,7-dione
EINECS	Contact for details

Quality Control

Our 1-Azabicyclo[3.2.0]Heptane-3,7-Dione,2-(1-Methylethyl)-,(2R-Cis)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical R&D and process development. Certificates of Analysis (COA) detailing identity, purity, and specific tests are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.