Description

Buprenorphine n-Oxide is a key pharmaceutical intermediate and metabolite of the opioid partial agonist buprenorphine. This compound is of significant interest in analytical chemistry and forensic toxicology for method development and reference standards. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories involved in drug metabolism studies, pharmacokinetic research, and the development of high-purity reference materials.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the calibration of analytical instruments and the validation of testing methods in quality control laboratories.
• Metabolite for Research: Used in preclinical and clinical research to study the metabolic pathways, pharmacokinetics, and pharmacodynamics of buprenorphine.
• Forensic Analysis: Employed as an analytical standard in forensic toxicology for the accurate identification and quantification of buprenorphine and its metabolites in biological samples.
• Method Development: Critical for developing and optimizing advanced chromatographic (HPLC, LC-MS/MS) and spectroscopic analytical methods.
• Impurity Profiling: Used in pharmaceutical manufacturing to identify and control process-related impurities and degradation products in buprenorphine API.

Basic Information

Product Name	Buprenorphine n-Oxide
CAS No.	112242-17-8
Molecular Formula	C₂₉H₄₁NO₅
Molecular Weight	483.64 g/mol
Synonyms	Buprenorphine N-Oxide; Buprenorphine N-Oxyde; 21-Cyclopropyl-7α-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine N-Oxide; Noroxymorphone, 21-cyclopropyl-7-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-etheno-6,7,8,14-tetrahydro-, N-oxide; Buprenorphine Impurity F (N-Oxide)
EINECS	Contact for details

Quality Control

Our Buprenorphine n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.