Description

Picumeterol CAS NO 112192-20-8 is a selective β-2 adrenergic receptor agonist, a potent bronchodilator of significant interest in pharmaceutical research and development. Its primary value lies in its potential for creating long-acting, highly specific therapeutic agents for respiratory conditions. This compound is essential for pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) focused on advancing treatments for asthma, chronic obstructive pulmonary disease (COPD), and related pulmonary disorders.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) for inhalation therapies.
• Respiratory Drug Research: Used in preclinical and clinical research to study β-2 adrenergic receptor mechanisms and develop new bronchodilators.
• Formulation Development: Employed in the development of metered-dose inhalers (MDIs), dry powder inhalers (DPIs), and nebulizer solutions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory compliance in pharmaceutical manufacturing.
• Biochemical Studies: Utilized in pharmacological assays to investigate receptor binding affinity and selectivity profiles.

Basic Information

Product Name	Picumeterol
CAS No.	112192-20-8
Molecular Formula	C20H24N2O5
Molecular Weight	372.42 g/mol
Synonyms	Picumeterol; 8-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]carbostyril; (R,R)-Formoterol; (R,R)-BD 40A; BD-40A; (R,R)-Formoterol Fumarate precursor; 4-Hydroxy-α1-[[[2-(4-methoxyphenyl)-1-methylethyl]amino]methyl]-3-(methylsulfonyl)benzyl alcohol (uncommon isomer designation).
EINECS	Contact for details

Quality Control

Our Picumeterol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral chromatography for enantiomeric excess, and identification via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed batch-specific results are provided and can be tailored to support regulatory filings (e.g., FDA, EMA).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (R,R-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.