Description

Silane, (6-Bromo-2-Hexynyl)Trimethyl- CAS NO 112129-48-3 is a specialized organosilicon compound featuring a bromoalkyne functional group, making it a valuable bifunctional reagent for advanced organic synthesis and materials science. Its unique structure allows it to serve as a versatile building block, enabling the precise introduction of both silyl and bromoalkyne moieties into target molecules. This compound is particularly essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced polymer industries who require high-purity intermediates for coupling reactions and surface modification.

Application

• Pharmaceutical Intermediate: Used in the synthesis of complex drug candidates, particularly in Sonogashira and other palladium-catalyzed cross-coupling reactions to create novel molecular architectures.
• Agrochemical Synthesis: Serves as a key precursor for developing new active ingredients with tailored properties for crop protection.
• Surface Modification Agent: Employed to functionalize silica, glass, or metal oxide surfaces, imparting specific chemical properties for coatings, adhesives, and composite materials.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the production of specialty silicones and hybrid organic-inorganic polymers.
• Liquid Crystal & OLED Materials: Utilized in the synthesis of advanced electronic and optoelectronic materials requiring precise molecular alignment.
• Bioconjugation Chemistry: Facilitates the site-specific labeling of biomolecules (proteins, peptides) due to its reactive alkyne and bromine handles.
• Click Chemistry: The bromoalkyne group is amenable to further functionalization via copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
• Research & Development: A critical tool in academic and industrial R&D labs for exploring new synthetic pathways and material properties.

Basic Information

Product Name	Silane, (6-Bromo-2-Hexynyl)Trimethyl-
CAS No.	112129-48-3
Molecular Formula	C9H17BrSi
Molecular Weight	233.22 g/mol
Synonyms	(6-Bromo-2-hexynyl)trimethylsilane; Trimethyl(6-bromohex-2-yn-1-yl)silane; 6-Bromo-2-hexynyltrimethylsilane; 1-Bromo-5-(trimethylsilyl)-4-pentyne; (6-Bromohex-2-yn-1-yl)trimethylsilane; Bromoalkynylsilane; TMS-protected bromoalkyne
EINECS	Contact for details

Quality Control

Our (6-Bromo-2-Hexynyl)Trimethylsilane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by GC/HPLC), identity (by FT-IR and NMR), and impurity profiles. Our quality management system is designed to meet the rigorous standards required for research and commercial scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.470 - 1.480
Density (g/mL, 25°C)	1.10 - 1.20

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.