Description

3 6-Di-o-(tert-Butyldimethylsilyl)-D- is a high-purity, protected carbohydrate derivative, specifically a silylated D-sugar intermediate. This compound is critical for synthetic organic chemistry, offering a robust protective group strategy that enables selective reactions in complex molecule assembly. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of nucleoside analogs, antiviral agents, and other fine chemicals where precise stereochemistry and functional group manipulation are paramount.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer research.
• Glycochemistry Research: Used as a protected glycosyl donor or acceptor in the stereoselective synthesis of complex oligosaccharides and glycoconjugates.
• Process Chemistry: Serves as a critical intermediate in the scalable production of active pharmaceutical ingredients (APIs) requiring sugar moiety modifications.
• Chemical Biology Probes: Foundation for creating labeled or modified sugar derivatives used to study biological recognition and metabolic pathways.
• Chiral Pool Synthesis: Provides a readily available, enantiomerically pure starting material for the asymmetric synthesis of natural products and specialty chemicals.

Basic Information

Product Name	3 6-Di-o-(tert-Butyldimethylsilyl)-D-
CAS No.	111902-03-5
Molecular Formula	C18H40O5Si2
Molecular Weight	392.68 g/mol
Synonyms	1,2-O-Isopropylidene-3,6-di-O-(tert-butyldimethylsilyl)-α-D-glucofuranose; 3,6-Bis-O-(tert-butyldimethylsilyl)-1,2-O-isopropylidene-α-D-glucofuranose; 1,2:5,6-Di-O-isopropylidene-3-O-(tert-butyldimethylsilyl)-α-D-allofuranose (related isomer); TBDMS-protected D-glucose derivative; 3,6-di-TBDMS-1,2-O-isopropylidene-α-D-glucofuranose; Protected D-glucofuranose intermediate; Silylated sugar intermediate
EINECS	Contact for details

Quality Control

Our 3 6-Di-o-(tert-Butyldimethylsilyl)-D- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee reproducible performance in your sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions, preferably in a controlled atmosphere or sealed with appropriate desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.