Description

2-Bromo-4,5,6,7-tetrahydro-1-benzothiophene is a versatile brominated heterocyclic building block of significant importance in advanced organic synthesis. Its core structure, featuring a tetrahydrobenzothiophene ring system, makes it a critical intermediate for the development of complex molecules, particularly in pharmaceutical research and material science. This compound is primarily sought after by R&D chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the benzothiophene scaffold.
• Material Science Research: Used in the synthesis of organic semiconductors, ligands for catalysis, and other specialty chemicals requiring a functionalized, fused-ring system.
• Chemical Biology & Proteomics: Can be utilized as a molecular probe or a tag in bioconjugation chemistry due to its reactive bromine handle.
• Academic & Industrial R&D: Essential for method development, library synthesis, and exploring new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	2-Bromo-4,5,6,7-tetrahydro-1-benzothiophene
CAS No.	111873-07-5
Molecular Formula	C8H9BrS
Molecular Weight	217.13 g/mol
Synonyms	2-Bromotetrahydrobenzo[b]thiophene; 2-Bromo-4,5,6,7-tetrahydrobenzo[b]thiophene; 4,5,6,7-Tetrahydro-2-bromobenzo[b]thiophene; 2-Bromo-4,5,6,7-tetrahydro-1-benzothiophene; 2-Bromocyclohexano[b]thiophene; 2-Bromo-4,5,6,7-tetrahydrobenzo[b]thienyl; 2-Bromotetrahydrobenzothiophene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,5,6,7-tetrahydro-1-benzothiophene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data including HPLC purity, NMR, and GC-MS for identity confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, and custom synthesis to meet specific purity or packaging requirements is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.