Description

α-Chloro-α-Bromophosphonoacetic Acid is a highly reactive organophosphorus compound that serves as a critical synthetic intermediate. Its unique bifunctional halogenated structure makes it a valuable building block for constructing complex molecules with tailored properties. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those with phosphonate or phosphate ester functionalities, such as protease inhibitors or nucleotide analogs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, plant growth regulators, and insecticides where the phosphonoacetic acid moiety is required for bioactivity.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized chelating ligands or organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the creation of functionalized polymers, surface modifiers, and flame retardants due to its reactive halogen and phosphonate groups.
• Chemical Biology Probes: Utilized to develop activity-based probes and molecular tools for studying enzyme mechanisms, particularly those involving phosphorylation.

Basic Information

Product Name	α-Chloro-α-Bromophosphonoacetic Acid
CAS No.	111863-21-9
Molecular Formula	C2H3BrClO4P
Molecular Weight	237.37 g/mol
Synonyms	α-Chloro-α-bromophosphonoacetic Acid; (Bromochloromethyl)phosphonic Acid; Phosphonoacetic Acid, α-chloro-α-bromo-; Bromochloromethylphosphonic Acid; 2-Bromo-2-chloro-2-phosphonoacetic Acid
EINECS	Contact for details

Quality Control

Our α-Chloro-α-Bromophosphonoacetic Acid is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.