Description

(7-Hydroxy-6-Methoxy-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Acetic Acid is a high-purity synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of complex molecules, particularly those targeting neurological and cardiovascular pathways. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require reliable, high-quality intermediates for API synthesis and novel drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds with tetrahydroisoquinoline scaffolds.
• Medicinal Chemistry Research: Used as a versatile building block for constructing novel chemical entities in drug discovery, enabling structure-activity relationship (SAR) studies.
• Neurological Drug Development: Employed in the research and synthesis of potential therapeutics targeting central nervous system (CNS) disorders.
• Cardiovascular Agent Synthesis: Serves as an intermediate for developing compounds with potential vasodilatory or cardioprotective properties.
• Alkaloid Analog Synthesis: Used to create synthetic analogs of naturally occurring isoquinoline alkaloids for biological evaluation.
• Process Chemistry & Scale-Up: Provides a defined starting material for optimizing synthetic routes and scaling up production under cGMP conditions.

Basic Information

Product Name	(7-Hydroxy-6-Methoxy-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Acetic Acid
CAS No.	111599-06-5
Molecular Formula	C₁₂H₁₅NO₄
Molecular Weight	237.25 g/mol
Synonyms	1,2,3,4-Tetrahydro-7-hydroxy-6-methoxy-1-isoquinolineacetic acid; 2-(7-Hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetic acid; 7-Hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-acetic acid; (7-Hydroxy-6-methoxy-1,2,3,4-tetrahydro-1-isoquinolyl)acetic acid; THIQ-acetic acid derivative; Isoquinoline acetic acid derivative
EINECS	Contact for details

Quality Control

Our (7-Hydroxy-6-Methoxy-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP requirements. Specifications can be tailored to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.