Description

4-Hydroxyphenobarbital-D5 is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative analyses in complex matrices. It is primarily used by analytical laboratories and research institutions in the pharmaceutical and forensic toxicology sectors for method development and validation.

Application

• Internal Standard for LC-MS/MS and GC-MS quantification of phenobarbital and its metabolites.
• Method Development and Validation in pharmaceutical bioanalysis and clinical research.
• Metabolite Studies for investigating the metabolic pathways of barbiturates.
• Forensic Toxicology Analysis for precise and legally defensible drug level determinations.
• Quality Control in pharmaceutical manufacturing to monitor process-related impurities.
• Stable Isotope Dilution Assays (SIDA) for achieving high-precision analytical results.

Basic Information

Product Name	4-Hydroxyphenobarbital-D5
CAS No.	111342-31-5
Molecular Formula	C12H7D5N2O3
Molecular Weight	235.26 g/mol (for deuterated form)
Synonyms	5-Ethyl-5-(4-hydroxyphenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione-d5; Phenobarbital-4-hydroxy-d5; 4'-Hydroxyphenobarbital-d5; 5-Ethyl-5-(4-hydroxyphenyl)barbituric acid-d5; Deuterated 4-Hydroxyphenobarbital; [D5]-4-Hydroxyphenobarbital; 4-OH Phenobarbital-D5
EINECS	Contact for details

Quality Control

Our 4-Hydroxyphenobarbital-D5 is manufactured under strict quality systems to ensure the high isotopic purity and chemical stability required for sensitive analytical applications. Each batch is accompanied by comprehensive analytical data, including NMR and mass spectrometry for isotopic enrichment verification. Certificates of Analysis (COA) detailing purity, chemical purity, and isotopic abundance are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (by NMR)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.