Description

4-Bromo-3-Thiophenesulfonyl Chloride is a high-purity organosulfur building block of significant importance in advanced organic synthesis. This compound serves as a versatile electrophilic reagent for introducing the 4-bromo-3-thiophenesulfonyl moiety, a key functional group in the development of complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the thiophene scaffold imparts specific biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of conductive polymers, organic semiconductors, and advanced electronic materials.
• Chemical Biology Probe Development: Employed to create sulfonamide-based probes and ligands for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific sulfonyl chloride functionalities.

Basic Information

Product Name	4-Bromo-3-Thiophenesulfonyl Chloride
CAS No.	111283-90-0
Molecular Formula	C4H2BrClO2S2
Molecular Weight	261.55 g/mol
Synonyms	3-Thiophenesulfonyl chloride, 4-bromo-; 4-Bromothiophene-3-sulfonyl chloride; 4-Bromo-3-thienylsulfonyl chloride; 4-Bromothiophene-3-sulphonyl chloride; 4-Bromo-3-thiophenesulfonylchloride; 111283-90-0; 4-Bromo-thiophene-3-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Thiophenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.