Description

Gla 60 is a high-purity, light-sensitive glycolic acid derivative widely used as a specialty intermediate in pharmaceutical synthesis and advanced polymer production. Its controlled reactivity and defined stereochemical profile make it critical for manufacturing high-value active pharmaceutical ingredients (APIs) and biodegradable polyesters. Pharmaceutical R&D labs, contract development and manufacturing organizations (CDMOs), and high-performance polymer producers rely on Gla 60 CAS NO 111247-04-2 for reproducible, scalable syntheses requiring strict impurity control.

Application

• Key chiral building block in the synthesis of β-hydroxy acid-based APIs, including antifungal and anti-inflammatory agents
• Monomer precursor for poly(glycolic acid)-co-poly(lactic acid) (PLGA) copolymers used in controlled-release drug delivery systems
• Intermediate in the production of photo-labile protecting groups for solid-phase peptide synthesis
• Coupling agent in the preparation of bioresorbable surgical sutures and tissue engineering scaffolds
• Reagent in asymmetric catalysis for enantioselective esterification and transesterification reactions
• Stabilized platform for developing prodrugs with enhanced membrane permeability and hydrolytic tunability

Basic Information

Product Name	Gla 60
CAS No.	111247-04-2
Molecular Formula	C4H6O5
Molecular Weight	134.09 g/mol
Synonyms	Glycolic acid 60% aqueous solution; Glycolic acid monohydrate (60% w/w); GLA-60; 60% Glycolic Acid Solution; Hydroxyacetic acid 60%; 2-Hydroxyacetic acid 60%; Glycolic acid (aqueous, ~60%); CAS 111247-04-2
EINECS	Not listed (EINECS entry not assigned for this specific concentration grade)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to stringent specifications for identity, assay, residual solvents, heavy metals, and microbial limits — meeting requirements for pharmaceutical intermediate use under ICH Q7 guidelines. Testing includes HPLC purity determination, IR spectral confirmation, Karl Fischer moisture analysis, and ICP-MS trace metal screening.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Avoid exposure to air and moisture due to its easily oxidized nature. Do not store near strong oxidizing agents or alkaline materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identity (IR)	Conforms to reference standard
Assay (by titration)	58.0 – 62.0% w/w glycolic acid
pH (10% aqueous)	1.8 – 2.4
Residue on ignition	≤ 0.1%
Heavy metals (as Pb)	≤ 10 ppm
Chloride (Cl⁻)	≤ 50 ppm
Sulfate (SO₄²⁻)	≤ 100 ppm
Related substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.