Description

1,5-Benzothiazepin-4(5H)-One, 3-(Acetyloxy)-5-[2-(Dimethylamino)Ethyl]-2,3-Dihydro-2-(4-Methoxyphenyl)-, (2R-Trans)- is a high-purity, chiral benzothiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or a potential pharmacophore for the creation of novel therapeutic agents targeting the cardiovascular and central nervous systems. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly for cardiovascular and neurological applications.
• Chemical Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical analysis.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore and optimize biological activity.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for studying benzothiazepine chemistry and its biological interactions.

Basic Information

Product Name	1,5-Benzothiazepin-4(5H)-One, 3-(Acetyloxy)-5-[2-(Dimethylamino)Ethyl]-2,3-Dihydro-2-(4-Methoxyphenyl)-, (2R-Trans)-
CAS No.	111188-71-7
Molecular Formula	C22H26N2O4S
Molecular Weight	414.52 g/mol
Synonyms	(2R-trans)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one; trans-2,3-Dihydro-3-acetoxy-2-(p-methoxyphenyl)-5-[2-(dimethylamino)ethyl]-1,5-benzothiazepin-4(5H)-one; Diltiazem Intermediate; Diltiazem Related Compound; Benzothiazepine Derivative
EINECS	Contact for details

Quality Control

Our 1,5-Benzothiazepin-4(5H)-One derivative is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant quality management standards to support our global clientele in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R-trans)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.