Description

3-Methyl-D3-Adenine is a deuterated derivative of the autophagy inhibitor 3-Methyladenine, where three hydrogen atoms are replaced with deuterium. This isotopic labeling is crucial for enhancing metabolic stability and providing a non-radioactive tracer for advanced pharmacokinetic and drug metabolism studies. It is an essential research-grade biochemical for pharmaceutical R&D, particularly in the fields of oncology, neurobiology, and metabolic disease research where precise tracking of molecular pathways is required.

Application

• Pharmacokinetic & Drug Metabolism Studies (DMPK): Used as an internal standard in LC-MS/MS for the quantitative bioanalysis of 3-Methyladenine, ensuring accurate measurement of drug concentration in biological matrices.
• Mechanistic Biomedical Research: Serves as a stable isotope-labeled probe to investigate autophagy pathways and their role in diseases such as cancer, neurodegenerative disorders, and aging.
• Isotope Dilution Mass Spectrometry: Employed in high-precision analytical methods to improve accuracy and reliability in quantifying endogenous compounds or drug metabolites.
• Pharmaceutical Reference Standard: Acts as a certified reference material (CRM) for method development, validation, and quality control in drug discovery and development pipelines.
• Biochemical Pathway Tracing: Utilized in metabolic flux analysis to trace the fate of adenine derivatives within complex biological systems without radioactive hazards.

Basic Information

Product Name	3-Methyl-D3-Adenine
CAS No.	110953-39-4
Molecular Formula	C6D3H4N5
Molecular Weight	151.17 g/mol
Synonyms	3-MA-d3; 3-Methyladenine-d3; 6-Amino-3-(methyl-d3)-9H-purine; Deuterated 3-Methyladenine; 3-Methyl(trideuteriomethyl)adenine; N6-Methyl-d3-adenine; 3-Methyladenine (trideuterated); 3-MA (deuterated)
EINECS	Contact for details

Quality Control

Our 3-Methyl-D3-Adenine is manufactured under strict quality management systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and Mass Spectrometry, to confirm deuteration level and chemical purity. Certificates of Analysis (COA) detailing batch-specific results for identity, purity (HPLC), isotopic enrichment (D%), and residual solvents are provided. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.