Description

(+/-)-Cotinine-D3 CAS NO 110952-70-0 is a deuterium-labeled isotopologue of cotinine, a major metabolite of nicotine, serving as a critical internal standard for analytical quantification. Its primary value lies in enabling highly accurate and reliable mass spectrometry-based measurements in complex biological matrices. This compound is essential for researchers and laboratories in the pharmaceutical, clinical diagnostics, and toxicology sectors who require precise quantification of nicotine and its metabolites for pharmacokinetic studies, smoking cessation research, and forensic analysis.

Application

• Internal Standard for LC-MS/MS and GC-MS analysis of nicotine and its metabolites in biological samples (e.g., plasma, urine, saliva).
• Quantitative biomarker research for smoking behavior, exposure assessment, and nicotine metabolism studies.
• Method development and validation in clinical and forensic toxicology laboratories.
• Pharmacokinetic and pharmacodynamic studies in pharmaceutical R&D for nicotine replacement therapies.
• Quality control and reference standard in the manufacturing of diagnostic kits and assays.
• Environmental and occupational health research monitoring second-hand smoke exposure.

Basic Information

Product Name	(+/-)-Cotinine-D3
CAS No.	110952-70-0
Molecular Formula	C10H9D3N2O
Molecular Weight	179.23 g/mol
Synonyms	Cotinine-d3; (RS)-Cotinine-d3; 5-(3-Pyridinyl)-1-methyl-2-pyrrolidinone-d3; DL-Cotinine-d3; (±)-Cotinine-d3; 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone-d3; Nicotine metabolite-d3; Cotinine (methyl-d3)
EINECS	Contact for details

Quality Control

Our (+/-)-Cotinine-D3 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including NMR, HPLC, and mass spectrometry. We ensure compliance with relevant standards for research and diagnostic use, and custom specifications are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.