Description

n-tert-Butoxycarbonyl-3-Mercapto-L-Valine is a protected amino acid derivative of significant importance in advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex peptides and peptidomimetics, particularly those requiring the incorporation of a thiol-functionalized valine residue. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting viral proteases and other enzymes.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected 3-mercapto-L-valine moiety into peptide chains.
• Peptidomimetic Research: Facilitates the creation of peptidomimetics where the thiol group can be used for further conjugation, cyclization, or to mimic disulfide bonds.
• Bioconjugation Chemistry: The tert-butoxycarbonyl (Boc) protecting group allows for orthogonal deprotection strategies, making it valuable for constructing complex biomolecular conjugates.
• Ligand Development: Employed in the development of custom ligands and chelating agents for catalysis or metal-binding applications.
• Academic & R&D: Serves as a valuable reagent in university and industrial research laboratories for methodological development and exploring new chemical entities.

Basic Information

Item	Detail
Product Name	n-tert-Butoxycarbonyl-3-Mercapto-L-Valine
CAS No.	110763-40-1
Molecular Formula	C10H19NO4S
Molecular Weight	249.33 g/mol
Synonyms	Boc-3-mercapto-L-valine; (2S)-3-Mercapto-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid; N-Boc-3-mercapto-L-valine; Boc-L-Valine(3-SH); N-(tert-Butoxycarbonyl)-3-mercapto-L-valine; 3-Mercapto-L-valine, N-Boc derivative; tert-Butyl (1-((S)-1-carboxy-2-mercaptopropyl)carbamate)
EINECS	Contact for details

Quality Control

Our n-tert-Butoxycarbonyl-3-Mercapto-L-Valine is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.