Description

Dmt-Dcytidine (N6-Benzoyl) Cyanoethyl Phosphoramidite is a highly specialized phosphoramidite monomer used in the automated solid-phase synthesis of oligonucleotides. This compound is critical for the precise and efficient incorporation of modified cytidine bases into DNA and RNA sequences. It is an essential raw material for research institutions, diagnostic developers, and pharmaceutical companies engaged in antisense therapy, siRNA development, and molecular diagnostics.

Application

• Oligonucleotide Synthesis: Primary building block for the automated synthesis of DNA and RNA strands containing modified cytidine.
• Therapeutic Oligonucleotide Production: Manufacture of active pharmaceutical ingredients (APIs) for antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) therapies.
• Diagnostic Probe Development: Creation of labeled probes and primers for PCR, qPCR, and next-generation sequencing (NGS) applications.
• Research Grade Nucleotide Synthesis: Production of custom oligonucleotides for basic biochemical and biophysical research.
• Antisense Drug Discovery: Key reagent in the research and development pipeline for novel genetic medicines.
• Synthesis of Modified Nucleic Acids: Enables the study of structure-function relationships by incorporating specific base modifications.

Basic Information

Product Name	Dmt-Dcytidine (N6-Benzoyl) Cyanoethyl Phosphoramidite
CAS No.	110522-84-4
Molecular Formula	C41H49N4O8P
Molecular Weight	756.83 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N4-benzoyl-2'-deoxycytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DMT-dC(Bz) Phosphoramidite; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); dC(Bz) Phosphoramidite; 2'-Deoxycytidine, N4-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
EINECS	Contact for details

Quality Control

Our Dmt-Dcytidine (N6-Benzoyl) Cyanoethyl Phosphoramidite is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive oligonucleotide synthesis. Each batch is tested to meet stringent specifications for identity, purity, and moisture content. Certificates of Analysis (COA) with detailed HPLC, NMR, and 31P NMR data are provided to guarantee compliance with your research or cGMP production needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. Due to its hygroscopic and easily oxidized nature, the product should be handled in a controlled, dry atmosphere and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure (1H, 31P)
Purity (HPLC)	≥ 98.5%
Moisture Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.