Description

(S)-α-Ethyl-α-Hydroxy-1,1-(Ethylenedioxy)-6-Hydroxymethyl-5-Oxo-1,2,3,5-Tetrahydroindolizine-7-[n-(1S)-1-Phenylethyl]Acetamide is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of chiral drugs where specific stereochemistry is essential for efficacy and safety. It is primarily utilized by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the production of sophisticated therapeutic agents.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of complex, chiral pharmaceutical compounds.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and optimization of new drug candidates, especially those targeting specific biological pathways.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for commercial drug manufacturing.
• Chiral Synthesis: Its defined stereochemistry makes it valuable for constructing molecules with specific three-dimensional configurations required for biological activity.
• Contract Manufacturing: Supplied to CMOs and fine chemical producers specializing in custom synthesis for the global pharmaceutical industry.

Basic Information

Product Name	(S)-α-Ethyl-α-Hydroxy-1,1-(Ethylenedioxy)-6-Hydroxymethyl-5-Oxo-1,2,3,5-Tetrahydroindolizine-7-[n-(1S)-1-Phenylethyl]Acetamide
CAS No.	110314-10-8
Molecular Formula	C25H32N2O7
Molecular Weight	472.53 g/mol
Synonyms	(S)-α-Ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydroindolizine-7-[N-[(1S)-1-phenylethyl]]acetamide; (S)-7-[N-[(1S)-1-Phenylethyl]acetamido]-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydroindolizine; Advanced Indolizine Intermediate; Chiral Indolizine Acetamide Derivative; CAS 110314-10-8
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support compliance with cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.