Description

(2R,4R)-3-Acetyl-2-(4-Fluorophenyl)-1,3-Thiazolidine-4-Carboxylic Acid is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial interest. Its value lies in its stereochemically defined structure, which is critical for synthesizing enantiomerically pure active pharmaceutical ingredients (APIs) with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or infectious diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in structure-activity relationship (SAR) studies and lead optimization programs.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to introduce complex molecular architectures.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development, validation, and quality control in API production.
• Bioconjugation & Prodrug Synthesis: The carboxylic acid and acetyl functionalities allow for derivatization to create prodrugs or bioconjugates with improved pharmacokinetic properties.

Basic Information

Product Name	(2R,4R)-3-Acetyl-2-(4-Fluorophenyl)-1,3-Thiazolidine-4-Carboxylic Acid
CAS No.	110078-80-3
Molecular Formula	C₁₂H₁₂FNO₃S
Molecular Weight	269.29 g/mol
Synonyms	(2R,4R)-3-Acetyl-2-(4-fluorophenyl)-1,3-thiazolidine-4-carboxylic acid; (2R,4R)-3-Acetyl-2-(p-fluorophenyl)thiazolidine-4-carboxylic acid; 3-Acetyl-2-(4-fluorophenyl)-1,3-thiazolidine-4-carboxylic acid, (2R,4R)-; (2R,4R)-2-(4-Fluorophenyl)-3-acetylthiazolidine-4-carboxylic acid; 110078-80-3; (2R-cis)-3-Acetyl-2-(4-fluorophenyl)-1,3-thiazolidine-4-carboxylic acid; (4R)-3-Acetyl-2-[(4-fluorophenyl)]-1,3-thiazolidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our (2R,4R)-3-Acetyl-2-(4-Fluorophenyl)-1,3-Thiazolidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical identity, meeting the stringent requirements for pharmaceutical R&D and cGMP intermediate production. Certificates of Analysis (COA) detailing purity (typically by HPLC), enantiomeric excess (ee), and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.