Description

Tiagabine CAS NO 109857-64-9 is a potent and selective GABA reuptake inhibitor, representing a significant class of neuroactive pharmaceutical compounds. Its primary value lies in its targeted mechanism of action, which is critical for modulating neuronal excitability in the central nervous system. This makes it an essential active pharmaceutical ingredient (API) for manufacturers in the pharmaceutical industry, particularly for the development and production of antiepileptic medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of antiepileptic drugs for the treatment of partial seizures.
• Neurological Research: A key reference standard and tool compound in preclinical studies investigating GABAergic neurotransmission and seizure mechanisms.
• Drug Development: Serves as a critical intermediate or finished API for companies developing generic or novel neurological therapeutics.
• Clinical Trial Material: Supplied under GMP conditions for use in Phase I-III clinical studies for new epilepsy treatments.
• Analytical Standard: Used in quality control laboratories for method development, validation, and assay calibration of tiagabine-based products.

Basic Information

Product Name	Tiagabine
CAS No.	109857-64-9
Molecular Formula	C20H25NO2S2
Molecular Weight	375.55 g/mol
Synonyms	Tiagabine Hydrochloride; (R)-(-)-Tiagabine; Gabitril; N-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]nipecotic Acid; NO-050328; NO 050328; NO050328; TGB
EINECS	Contact for details

Quality Control

Our Tiagabine is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to ensure identity, purity, strength, and composition, with testing typically including HPLC for assay and related substances, residual solvent analysis, and specific identification tests. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all test results against agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.