Description

(1S,2R)-(+)-trans-2-(1-Methyl-1-Phenylethyl)Cyclohexanol CAS NO 109527-45-9 is a chiral, non-racemic organic compound featuring a cyclohexanol core with a bulky, substituted phenyl group. This specific stereochemistry is critical for its role as a high-value chiral auxiliary, ligand, or building block in asymmetric synthesis. It is primarily sought after by research and development chemists in the pharmaceutical and fine chemical industries for the production of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to induce stereoselectivity in key bond-forming reactions such as alkylations, aldol reactions, and reductions.
• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of enantiomerically pure drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and other therapeutic areas.
• Ligand for Catalysis: Can be utilized in the development of chiral catalysts for transition metal-catalyzed asymmetric transformations.
• Fine Chemical Synthesis: Employed in the research-scale production of specialty chemicals, flavors, and fragrances where optical purity is paramount.
• Academic & Industrial Research: A valuable tool for methodological development in organic chemistry and for studying stereochemical outcomes in complex molecular systems.

Basic Information

Product Name	(1S,2R)-(+)-trans-2-(1-Methyl-1-Phenylethyl)Cyclohexanol
CAS No.	109527-45-9
Molecular Formula	C15H22O
Molecular Weight	218.33 g/mol
Synonyms	(+)-trans-2-(α-Cumyl)cyclohexanol; (1S,2R)-2-(1-Methyl-1-phenylethyl)cyclohexan-1-ol; (1S,2R)-2-(α,α-Dimethylbenzyl)cyclohexanol; (1S,2R)-(+)-2-(1-Phenyl-1-methylethyl)cyclohexanol; (+)-trans-2-(1-Phenyl-1-methylethyl)cyclohexanol; (1S,2R)-2-(2-Phenylpropan-2-yl)cyclohexan-1-ol; Chiral Cumyl Cyclohexanol Derivative
EINECS	Contact for details

Quality Control

Our production of (1S,2R)-(+)-trans-2-(1-Methyl-1-Phenylethyl)Cyclohexanol adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high enantiomeric excess (ee). Every lot is characterized using advanced analytical techniques, and a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profile is provided. We support cGMP-compliant manufacturing for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.