Description

p-Toluenesulfonylhydrazide-N,N,n-D3 is a deuterated derivative of p-toluenesulfonylhydrazide, a versatile chemical reagent. This isotopically labeled compound is critical for applications requiring precise tracking and analysis, such as in mechanistic studies and analytical method development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, stable-isotope labeled intermediates.

Application

• Pharmaceutical Research: Used as a deuterated reagent or intermediate in the synthesis of isotopically labeled active pharmaceutical ingredients (APIs) for metabolism, pharmacokinetic (DMPK), and bioanalytical studies.
• Analytical Chemistry: Serves as an internal standard in mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS) for the accurate quantification of its non-deuterated counterpart or related compounds.
• Mechanistic Studies: Employed as a tracer in chemical reaction mechanisms to elucidate pathways, particularly in reduction and decomposition reactions involving hydrazide reagents.
• Polymer & Materials Science: Acts as a chemical blowing agent or cross-linking agent precursor in the development of specialized polymeric materials, where the deuterium label aids in structural analysis.
• Agrochemical Development: Utilized in the synthesis of deuterated analogs of pesticides or herbicides for environmental fate and degradation studies.

Basic Information

Product Name	p-Toluenesulfonylhydrazide-N,N,n-D3
CAS No.	109333-73-5
Molecular Formula	C7H7D3N2O2S
Molecular Weight	187.24 g/mol (deuterated form)
Synonyms	4-Methylbenzenesulfonylhydrazide-N,N,n-D3; Tosylhydrazide-d3; p-Toluenesulfonhydrazide-d3; TsNHNHD2; Deuterated p-Toluenesulfonyl Hydrazide; N,N-Dideutero-p-toluenesulfonylhydrazide; 4-Tolylsulfonylhydrazide-d3; (4-Methylphenyl)sulfonylhydrazide-d3
EINECS	Contact for details

Quality Control

Our p-Toluenesulfonylhydrazide-N,N,n-D3 is manufactured under strict quality protocols to ensure high isotopic purity and chemical integrity, essential for research and analytical applications. Each batch is analyzed via NMR, HPLC, and MS to confirm deuterium incorporation, chemical purity, and identity. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.