Description

n-Hydroxysuccinimide Hippuran Ester is a specialized, high-purity active ester derivative used as a critical reagent in bioconjugation and peptide synthesis. This compound matters for its role in facilitating efficient and selective coupling reactions, particularly in the preparation of labeled compounds for diagnostic and research applications. It is primarily needed by pharmaceutical R&D teams, diagnostic kit manufacturers, and academic researchers working in radiopharmaceuticals, immunoassays, and targeted drug delivery systems.

Application

• Radiopharmaceutical Precursor: A key intermediate in the synthesis of iodine-131 labeled Hippuran (ortho-iodohippurate) for renal function diagnostics.
• Bioconjugation Reagent: Used to activate carboxylic acids for subsequent amide bond formation with amines on proteins, peptides, or other biomolecules.
• Peptide Synthesis: Employed in solid-phase and solution-phase peptide chemistry to incorporate specific functional groups or labels.
• Diagnostic Probe Development: Facilitates the creation of fluorescently or radio-labeled probes for in vitro and in vivo imaging studies.
• Antibody-Drug Conjugate (ADC) Research: Serves as a linker chemistry component in the early-stage development of targeted therapeutics.
• Biomarker Labeling: Enables the covalent attachment of tags to small molecule biomarkers for assay development.

Basic Information

Product Name	n-Hydroxysuccinimide Hippuran Ester
CAS No.	109032-43-1
Molecular Formula	C15H16N2O6
Molecular Weight	320.30 g/mol
Synonyms	N-Hippuryloxysuccinimide; Hippuryl N-Hydroxysuccinimide Ester; o-Iodohippuric Acid N-Hydroxysuccinimide Ester; NHS-Hippuran; Succinimidyl Hippurate; HIPPURAN NHS ester; N-Succinimidyl Hippurate; 2-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonylamino]benzoic Acid
EINECS	Contact for details

Quality Control

Our n-Hydroxysuccinimide Hippuran Ester is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR). Certificates of Analysis (COA) with detailed specifications are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; sparingly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.