Description

(+)-Ethotoin CAS NO 108739-43-1 is the enantiomerically pure form of the established anticonvulsant agent Ethotoin. This high-purity chiral compound is critical for advanced pharmaceutical research and development, particularly in the study of stereoselective drug action and metabolism. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development and analytical testing of enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification, purity assay, and impurity profiling of Ethotoin in quality control laboratories.
• Chiral Intermediate: Used as a key building block in the synthesis of more complex, stereochemically defined pharmaceutical compounds.
• Metabolic and Pharmacological Research: Employed in preclinical studies to investigate the specific biological activity, pharmacokinetics, and toxicity profile of the (+)-enantiomer.
• Analytical Method Development: Essential for developing and validating chiral separation methods, such as chiral HPLC or CE, for pharmaceutical analysis.
• Academic Research: Used in university and institutional labs for studies in medicinal chemistry, neuropharmacology, and stereochemistry.

Basic Information

Product Name	(+)-Ethotoin
CAS No.	108739-43-1
Molecular Formula	C11H12N2O2
Molecular Weight	204.23 g/mol
Synonyms	(+)-3-Ethyl-5-phenylhydantoin; (R)-3-Ethyl-5-phenylimidazolidine-2,4-dione; D-Ethotoin; (R)-Ethotoin; (+)-1-Ethyl-2,5-dioxo-4-phenylimidazolidine; NSC 32999; (R)-3-Ethyl-5-phenyl-2,4-imidazolidinedione
EINECS	Contact for details

Quality Control

Our (+)-Ethotoin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet the stringent requirements for pharmaceutical research standards. A detailed Certificate of Analysis (COA) providing results for assay, chiral purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.