Description

Guanidine-D5 Hydrochloride is a stable isotope-labeled derivative of guanidine hydrochloride, where five hydrogen atoms are replaced by deuterium. This compound is essential as an internal standard in quantitative mass spectrometry, providing unmatched accuracy and precision for analytical method development and validation. It is a critical reagent for researchers and quality control laboratories in the pharmaceutical, biotechnology, and metabolomics sectors who require high-fidelity isotopic purity for pharmacokinetic studies, biomarker discovery, and proteomic analysis.

Application

• Quantitative Mass Spectrometry (MS): Serves as a crucial internal standard for the accurate quantification of guanidine and related compounds in complex biological matrices.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of drug candidates.
• Proteomics and Protein Chemistry: Employed in studies involving protein denaturation and folding where deuterated analogs help minimize interference in analytical measurements.
• Clinical Diagnostics and Biomarker Analysis: Facilitates the precise measurement of endogenous metabolites in serum, plasma, or urine for disease biomarker validation.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Acts as a deuterated agent in select NMR applications to study molecular structure and dynamics.
• Metabolomics and Stable Isotope Tracing: Enables precise flux analysis in metabolic pathway studies within cell cultures or model organisms.

Basic Information

Product Name	Guanidine-D5 Hydrochloride
CAS No.	108694-93-5
Molecular Formula	C¹H¹D⁵N₃·HCl
Molecular Weight	101.59 g/mol
Synonyms	Guanidine-d5 hydrochloride; Guanidine-¹H₅ hydrochloride; (Aminoiminomethyl-d₂)-d₃-amine hydrochloride; Deuterated guanidine hydrochloride; Guanidine-D5 HCl; Aminoformamidine-D5 hydrochloride; Carbamamidine-D5 hydrochloride; Isotopic internal standard for guanidine
EINECS	Contact for details

Quality Control

Our Guanidine-D5 Hydrochloride is manufactured under strict quality systems to ensure high isotopic and chemical purity suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity, and absence of critical impurities. We support compliance with cGMP and ICH guidelines for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Handle and open containers under dry, inert conditions when possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.