Description

Dl-Homocystine (3,3,3',3',4,4,4',4'-D8) is a deuterium-labeled analog of the amino acid derivative homocystine, specifically designed for research and analytical applications. This stable isotope-labeled compound is essential for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic pathway tracing in complex biological matrices. It is a critical tool for researchers and analytical laboratories in the fields of metabolomics, clinical diagnostics, and pharmaceutical development, where accurate measurement of sulfur-containing amino acids is required.

Application

• Internal Standard for Mass Spectrometry (MS): Primary application for quantitative analysis using LC-MS/MS and GC-MS methods in bioanalytical studies.
• Metabolomics Research: Used to investigate metabolic flux and disorders related to homocysteine metabolism, such as hyperhomocysteinemia.
• Clinical Diagnostic Assay Development: Serves as a reference standard in the development and validation of assays for homocysteine and related metabolites in plasma or serum.
• Pharmaceutical R&D: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug candidates and their effects on sulfur amino acid pathways.
• Nutritional Science: Used in studies examining the impact of diet, vitamins (B6, B12, folate), and supplements on homocysteine levels.
• Isotope Dilution Analysis: Critical for high-precision quantification in environmental, food, and biochemical analysis to correct for sample loss and instrument variability.

Basic Information

Product Name	Dl-Homocystine (3,3,3',3',4,4,4',4'-D8)
CAS No.	108641-82-3
Molecular Formula	C8H8D8N2O4S2
Molecular Weight	284.40 g/mol
Synonyms	DL-Homocystine-d8; (R*,S*)-4,4'-Dithiobis[2-aminobutanoic acid]-3,3,3',3',4,4,4',4'-d8; Homocystine-d8; 2,2'-Diamino-4,4'-dithiodibutanoic acid-d8; (dl)-Homocystine-d8; Deuterated DL-Homocystine; Perdeuterated DL-Homocystine (on specified carbons); Stable Isotope Labeled Homocystine
EINECS	Contact for details

Quality Control

Our deuterated biochemicals are produced and controlled under a strict quality management system. Each batch of Dl-Homocystine-d8 is analyzed to confirm isotopic purity (atom % D), chemical purity, and identity. Certificates of Analysis (COA) are provided, detailing results from NMR, HPLC, and MS analysis. We support research requiring traceability and consistency, with specifications tailored to meet the rigorous demands of GLP and ISO-compliant laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (by NMR or MS)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.