Description

(S)-1-(4-Chlorophenoxy)-3-Mercaptopropan-2-Ol is a chiral organic compound featuring both a mercaptan (thiol) and a secondary alcohol functional group. This unique structure makes it a valuable chiral building block and intermediate in sophisticated organic synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries. The compound is utilized for the construction of complex molecules where stereochemical control is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of β-blockers, anti-inflammatory agents, or other therapeutics where the (S)-enantiomer is required for efficacy.
• Agrochemical Synthesis: Used in the research and production of chiral pesticides, herbicides, or fungicides, where the specific stereochemistry can influence potency and environmental degradation profiles.
• Ligand and Catalyst Precursor: Serves as a starting material for the preparation of chiral ligands used in asymmetric catalysis, such as in transition metal complexes for enantioselective hydrogenation or cross-coupling reactions.
• Biochemical Research: Employed in studies involving enzyme inhibition or as a substrate analog in metabolic pathway investigations due to its thiol and alcohol moieties.
• Material Science Intermediate: Potential use in the synthesis of specialty polymers or functional materials where the incorporation of a thiol group is needed for further cross-linking or modification.

Basic Information

Product Name	(S)-1-(4-Chlorophenoxy)-3-Mercaptopropan-2-Ol
CAS No.	108615-59-4
Molecular Formula	C9H11ClO2S
Molecular Weight	218.70 g/mol
Synonyms	(S)-1-(4-Chlorophenoxy)-3-mercapto-2-propanol; (S)-3-Mercapto-1-(4-chlorophenoxy)-2-propanol; (S)-1-(p-Chlorophenoxy)-3-mercapto-2-propanol; (S)-Glycidyl 4-chlorophenyl ether thiol adduct; (2S)-1-(4-Chlorophenoxy)-3-sulfanylpropan-2-ol; (S)-(-)-1-(4-Chlorophenoxy)-3-mercapto-2-propanol; SH-Containing chiral epoxide derivative
EINECS	Contact for details

Quality Control

Our (S)-1-(4-Chlorophenoxy)-3-Mercaptopropan-2-Ol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure high chemical and enantiomeric purity suitable for advanced synthetic applications. A detailed Certificate of Analysis (COA) providing identity, assay, impurity profile, and specific rotation data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and degradation of the thiol group. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.